Fluoride: USNIH gives researchers money TO FIND OUT what fluorides are really doing to people

USNIH gives researchers money TO FIND OUT what fluorides are really doing to people.
See: http://grants.nih.gov/grants/guide/pa-files/PA-01-121.html (RESEARCH ON FLUORIDES TO IMPROVE ORAL HEALTH).

How many more admissions of official ignorance will it take to open the eyes of some of our elected representatives and water companies? This is evidence that authorities who parrot that fluoride-dosing is safe DO NOT KNOW KNOW ANY SUCH THING. And that's precisely what we've been saying from the outset.

Here's how Sally Stride reports it:
http://www.suite101.com/article.cfm/11749/81104 What Dentists Do Not Know About Fluoride
Author: Sally Stride
Published on: October 1, 2001

Government officials and organized dentistry tout fluoridation as one of public health’s greatest achievements and, often, insult or denigrate those opposed. As Americans slurp down glorified fluoride-laced water and beverages, their bodies and tax dollars are offered up to scientists to find out exactly what fluoride does to humans.

National Institutes of Dental and Craniofacial Research (NIDCR) grants, up to $250,000 annually, are offered to scientists to learn how to discern when fluoride’s benefits turn into risks, the overall metabolism of fluoride, and how it affects bones and teeth - something we hoped was known before adding fluorides to more than 144 million American’s drinking water since 1945 and, hence, most of America’s food supply.

While much evidence of fluoride’s harm stays buried in the scientific literature, these side effects are officially recognized but little publicized - black, tarry stools; bloody vomit; diarrhea; drowsiness; faintness; increased watering of mouth; nausea or vomiting; shallow breathing; stomach cramps or pain; tremors; unusual excitement; watery eyes; weakness. Early symptoms of possible chronic overdose are pain and aching of bones; skin rash; sores in the mouth and on the lips; stiffness; white, brown, or black discoloration of teeth(1)

Skeletal fluorosis, a crippling, deforming, arthritic-like disease can occur from drinking water with fluoride levels higher than 4 parts per million, according to The Environmental Protection Agency(3).

And we know that silicofluorides, used by 90% of fluoridating communities, have never been tested for health effects (4)

This is what else your government needs to learn about the fluoride you drink, from a NIDCR Program Announcement(2):

the current impact of water fluoridation and other fluoride modalities on dental caries and dental fluorosis on large populations

the overall metabolism of fluoride

effects of fluoride on bone and teeth

the development of “gold standard” methods for fluoride analysis of a wide variety of sample types

the influence of environmental factors on the effectiveness of fluoride, including temperature, altitude, food components, nutrients, and food additives

the development of biomarkers for monitoring body fluoride burden

noninvasive methods to quantify fluorosis in the body.

bioavailability, intake and excretion of fluoride

the influence of environment, genetics, nutrition, physiology and socio-economic and cultural diversity on the uptake, metabolism and biological and cosmetic effects of fluoride.

The following critical information is unclear according to the NIDCR:

The minimal effective fluoride level in human body to prevent and control dental caries without increasing the risk of dental fluorosis is still not established.

The cellular and molecular mechanism mediating anti-caries effects is unclear.

The interactions between fluoride and other food components remain undefined; for example, it has been implicated that some food preservatives such as benzoate can increase fluoride effects, but its underlying mechanism has not been fully studied.

Fluoride monitoring needs more convenient and accurate “gold standard measurement” of body fluoride burden, which can be used to determine fluoride in environment, foods, and body fluids and tissues.

Appropriate topics for investigation under this PA include, but are not limited to studies:

To elucidate the molecular mechanisms of the action of fluoride on tooth and bone cells. These investigations might include the effects of fluoride on: o Expression of genes that play a critical role in tooth and bone development and mineralization; o Proteins and other factors participating in tooth and bone development and mineralization; o Intracellular signaling systems regulating tooth and bone mineralization.

To determine the relative contribution of pre-eruptive and post- eruptive effects of fluoride on prevention of dental caries.

To determine the target concentration of fluoride in the oral environment to optimize the local action of fluoride for caries prevention.

To develop new generations of fluoride therapeutics, local delivery systems or devices to produce long-lasting and appropriate concentration of active fluoride compounds which provide better efficacies, better cost-effectiveness, and an improved safety profile. These new therapeutics will be specific for target tissues, and present in low levels in non-target tissues.

To investigate the interactions between fluorides and food components, nutrients and additives, and to develop methods to enhance the beneficial effect of fluoride.

To investigate the influence of environmental factors including temperature and altitude on the effectiveness of fluoride.

To develop simple global “gold standard” measurements, which are more accurate, rapid and convenient analyses for monitoring of fluoride levels such as screening, pharmacokinetics, time course determination, and other purposes in body fluids and other specimens including blood, saliva, urine and hair.

To ascertain the relative contribution of currently available fluoride modalities on dental caries prevention and control and on dental fluorosis in populations.

To investigate skeletal fluorosis and other fluoride effects on bone in areas with high concentrations of natural fluoride, including identification of environmental, cultural and social factors associated with excessive fluoride exposure, the pathogenesis of skeletal fluorosis, and development of valid and noninvasive methods to quantify fluorosis in vivo and to identify risk indicators or markers for dental fluorosis.

To measure the public health cosmetic significance of enamel opacities/fluorosis across cultures, and to explore preventive and therapeutic interventions for both enamel and skeletal fluorosis.
(1)http://www.nlm.nih.gov/medlineplus/drugi...
(2) http://grants.nih.gov/grants/guide/pa-fi...
(3) http://www.epa.gov/REDs/0087.pdf
(4) http://www.dartmouth.edu/~rmasters/lette...

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